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. 2018 Mar 7;13:39. doi: 10.1186/s13014-018-0984-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — In vitro effects of nimorazole on radiotherapy (RT) response. (a) Normoxia; Hypoxia; Normoxia + nimorazole; Hypoxia + nimorazole. Dose-response curve of MTS-assay with RT doses (x-axis, logarithmic) and cell viabilities (y-axis, mean, SD, non-linear regression fitted curve) relative to controls (0 Gy, cell viability = 100%). (b) ID50 = Radiation Dose (RD) to inhibit 50% of the cell viability; OER_D50 = Oxygen Enhancement Ratio (RD hypoxia/normoxia); SER_D50 = Sensitizer Enhancement Ratio (RD hypoxia/hypoxia with nimorazole)

Inline graphic — In vitro effects of nimorazole on radiotherapy (RT) response. (a) Normoxia; Hypoxia; Normoxia + nimorazole; Hypoxia + nimorazole. Dose-response curve of MTS-assay with RT doses (x-axis, logarithmic) and cell viabilities (y-axis, mean, SD, non-linear regression fitted curve) relative to controls (0 Gy, cell viability = 100%). (b) ID50 = Radiation Dose (RD) to inhibit 50% of the cell viability; OER_D50 = Oxygen Enhancement Ratio (RD hypoxia/normoxia); SER_D50 = Sensitizer Enhancement Ratio (RD hypoxia/hypoxia with nimorazole)