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. Author manuscript; available in PMC: 2018 Mar 8.
Published in final edited form as: Cancer Chemother Pharmacol. 2010 Sep 17;67(2):481–487. doi: 10.1007/s00280-010-1463-1

Fig. 3.

Fig. 3

A23187 uniformly decreases cell survival in pancreatic and lung cancer cell lines. BxPC-3 (pancreatic), having wild-type K-Ras gene; PanC-1 (pancreatic) cancer cells, having a mutation (G–D) at codon 12 in K-Ras gene; A549, having a (G–S) mutation at codon 12 in the K-Ras gene; and SK-LU-1 lung cancer cells, having a mutation (G–D) at codon 12 in the K-Ras gene were treated with varying concentrations of the calcium ionophore A23187 (0–100 µM) for 24 h to examine the effects on cell survival as analyzed by Sulforhodamine B assay. IC50 was determined by GraphPad Prism