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. Author manuscript; available in PMC: 2019 Feb 14.
Published in final edited form as: J Am Chem Soc. 2018 Feb 6;140(6):2301–2308. doi: 10.1021/jacs.7b12368

Figure 4.

Figure 4

(A) 48-hour cell viability of HeLa cells incubated with pTP-Me (20, 40, 60, 80, 100, 200, 300, 400, and 500 μM) in combination with BAY (0, 8, 12, 16, and 20 μM). (B) Normalized Isobologram,34 (D) Combination Index (CI)34 plot and (D) Dose-Reduction Index (DRI)34 plots for the combination of pTP-Me and BAY. All the analysis shown in (C-D) was based on the combination: pTP-Me 20-500 μM and BAY 16, 20 μM, 18 data points in total.