Table 1.
Characteristics of the PWS and control groups.
| PWS participants n = 20 |
Control participants n = 40 |
Statistical test for group difference | |
|---|---|---|---|
| Age (years) | |||
| Mean (s) | 23.10 (2.367) | 22.88 (2.245) | t(58) = 0.342, ns |
| Range | 19.84–27.73 | 19.59–28.98 | |
| Sex | |||
| M:F | 14:6 | 26:14 | χ2(1) = 150, ns |
| BMI | |||
| Mean (s) | 30.09 (7.158) | 24.09 (3.798) | U = 175.50⁎⁎ |
| Range | 21.52–47.73 | 19.21–34.20 | |
| IQ | |||
| Mean (s) | 63.10 (11.863) | 112.93 (11.253) | t(58) = − 15.88⁎⁎ |
| Range | 48–95 | 81–123 | |
| Genetic subtype | 19 deletion | N/A | N/A |
| 1 UPD | |||
| Growth HT | |||
| n (%) | 17 (85%) | N/A | N/A |
| Sex HT | |||
| n (%) | 15 (75%) | N/A | N/A |
| Psychoactive medications (n) | |||
| All | 10 | NA | NA |
| Antidepressants | 7a | ||
| Antipsychotics | 3a | ||
| Benzodiazepines | 1a | ||
| Anticonvulsants | 1 | ||
| Anticholinergics (n) | 1a |
BMI: body mass index; F: female; HT: hormone treatment; IQ: intelligence quotient; M: male; n: number; N/A: not applicable; ns: nonsignificant; s: standard deviation; UPD: uniparental disomy.
⁎⁎
Significant at p < 0.001.
a
One participant was taking both an antidepressant and an antipsychotic; another was taking both an antidepressant and a benzodiazepine; another was taking both an antipsychotic and an anticholinergic.