Table 2.
Brain areas showing significant associations between baseline or pre- to post-induction changes in amygdala functional connectivity (Δ FC) and the examined New York Cognition Questionnaire (NYC-Q) factors, the shift in HR from pre- to post-induction (Δ HR), and the interaction of these two variables.
| Cluster |
Voxel |
||||||
|---|---|---|---|---|---|---|---|
| Contrast of interest | Brain area | Seed | k | p FWE | Side | T | MNI xyz |
| (1) WORDS | |||||||
| ΔFC (post-pre induction) | |||||||
| Pos. correlation with WORDS | |||||||
| Precentral gyrus | LA | 131 | 0.012 | R | 6.17 | 34–16 50 | |
| (2) WORDS × ΔHR | |||||||
| Baseline | |||||||
| WORDS × △HR | |||||||
| Precuneus | 270 | 0.000 | R | 4.86 | 16–54 48 | ||
| Superior frontal gyrus | RA | 305 | 0.001 | L | 5.09 | − 20 36 54 | |
| Middle frontal gyrus | L | 5.00 | − 38 26 46 | ||||
| Temporal fusiform cortex | 308 | 0.017 | R | 5.08 | 40–18 -30 | ||
| Temporal fusiform cortex | 105 | 0.002 | L | 4.85 | − 36 -14 -34 | ||
| Words/Images factor × Group (GAD, HC) | |||||||
| Parietal opercular cortex | RA | 184 | 0.003 | R | 4.63 | 42–26 16 | |
| ΔFC (post-pre induction) | |||||||
| WORDS × △HR | |||||||
| Frontal pole | RA | 112 | 0.025 | R | 5.28 | 26 48–2 | |
| Frontal pole | 1482 | 0.000 | L | 6.15 | − 28 48 36 | ||
| Cerebelllum | 464 | 0.000 | L | 5.65 | − 2 -40 − 16 | ||
| Inferior temporal gyrus | 135 | 0.000 | R | 5.45 | 50–56 -18 | ||
| Middle temporal gyrus | 207 | 0.001 | R | 5.16 | 56–22 -10 | ||
| Putamen | 124 | 0.000 | R | 5.42 | 32–4 -12 | ||
| Lat occipital cortex | 151 | 0.006 | R | 4.97 | 30–74 -28 | ||
| Precentral gyrus | LA | 144 | 0.006 | R | 6.33 | 38–12 52 | |
| Cerebellum, V | 242 | 0.000 | L | 6.40 | -16 -44 -18 | ||
| Paracingulate gyrus | 158 | 0.022 | R | 3.68 | 10 24 36 | ||
| Superior frontal gyrus | 215 | 0.000 | L | 6.14 | − 8 -38 52 | ||
| Posterior inf temporal gyrus | 198 | 0.000 | R | 6.04 | 46–28 -10 | ||
| Temporooccipital inf temporal gyrus | 192 | 0.004 | R | 5.97 | 56–66 -10 | ||
| Words/Images factor × Group (GAD, HC) | |||||||
| Precentral gyrus | RA/LA | 163 | 0.003 | L | 5.86 | − 44 -18 62 | |
| Postcentral gyrus | L | 5.14 | − 52 -18 52 | ||||
| Occipital cortex | 181 | 0.002 | R | 5.24 | 52–72 -8 | ||
| 124 | 0.016 | R | 5.34 | 28 38 30 | |||
| Sup frontal gyrus | 167 | 0.002 | R | 4.97 | 12 34 50 | ||
| (3) NEGATIVE | |||||||
| Baseline | |||||||
| Group × NEGATIVE interaction | |||||||
| Temporal pole | LA | 233 | 0.001 | R | 6.14 | 26 10–30 | |
| Middle temporal gyrus | 162 | 0.007 | R | 4.90 | 50 4–26 | ||
| Central opercular cortex | 185 | 0.003 | L | 5.97 | − 50 6–4 | ||
| 121 | 0.029 | R | 4.32 | 58 2 4 | |||
| ΔFC (post-pre induction) | |||||||
| Neg. correlation with NEGATIVE | |||||||
| Anterior cingulate cortex | RA | 104 | 0.041 | L | 6.16 | − 12 38 18 | |
| (4) VAGUE | |||||||
| Baseline | |||||||
| Neg. correlation with VAGUE | |||||||
| LA | 349 | 0.000 | R | 5.37 | 0 50–10 | ||
| ΔFC (post-pre induction) | |||||||
| Precuneus | 74 | 0.014 | R | 4,59 | 6–46 14 | ||