Fig. 5.

Effective connectivity of the ictal-onset zone (CCEP network amplitude, latency and baseline standard deviation and diffusion network streamline density) pooled across all patients. Shown are the median and interquartile range for four connection categories: in (connections towards ictal-onset contacts), out (connections away from ictal-onset contacts), within (connections between ictal-onset contacts) and outside (connections not involving ictal-onset contacts). Whiskers cover the range of data points no > 1.5 times the interquartile range. A higher CCEP amplitude and baseline standard deviation was observed for in connection categories, whereas a trend for higher distribution of CCEP amplitude and streamline density was found for within connections. For each connectivity measure a Wilcoxon rank sum test was performed to test for a difference in medians to the outside connection category. The significance of the test is indicated above each category (one, two, three and four stars indicate p-values less than or equal to 0.05, 0.01, 0.001 and 0.0001, respectively).