Fig. 9.

Examples of non-contiguous seizure spread networks in patient 3 (left), 6 (center) and 7 (right). Plausible routes of seizure spread through ictal-onset (green), early propagative (orange) and late propagative (red) contacts were observed when considering evidence of connectivity using either CCEPs (blue), diffusion tractography (red), or both (purple). Patient 3 had no non-contiguous seizure spread connections containing both effective and structural connection, although both modalities individually had connections from both onset to early and early to late propagative contacts, indicating a possible mechanism for non-contiguous seizure spread through intermediate early propagative locations. Patient 6 had connections from onset to early and early to late contacts when considering either or both modalities. Patient 7 had many connections containing both effective and structural connections and many possible routes of seizure spread when considering either or both modalities.