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. Author manuscript; available in PMC: 2018 Mar 8.
Published in final edited form as: Acta Oncol. 2017 Aug 22;56(11):1367–1373. doi: 10.1080/0284186X.2017.1348621

Figure 2.

Figure 2

(A) Measured RBE for 10% surviving fraction of non-small cell lung cancer (NSCLC) H460 and H1437 cells as a function of LET for a monoenergetic 79.7 MeV scanned proton beam. The RBE values are lower than 1.1 for low LET values at the entrance of the beam in the medium and increase linearly up to the Bragg peak, and then rapidly and non-linearly at points beyond the Bragg peak. Reproduced from Guan et al. [4] (B) Relative biological effectiveness as a function of depth along monoenergetic and modulated 62-MeV proton beams for the radioresistant glioma U87 cells. RBE values are relative to 225 kVp x-rays using proton alpha and beta values obtained by the linear quadratic model. Reproduced from Chaudhary et al. [7]