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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: ACS Biomater Sci Eng. 2017 Mar 13;4(2):378–387. doi: 10.1021/acsbiomaterials.7b00017

Figure 5.

Figure 5

(a) Three-dimensionally reconstituted image of microgel sensors encapsulated in various hydrogels. A collagenase solution was applied to the top of hydrogel and changes in F/F0 of the microgel sensors were analyzed as a function of space and time. Microgel sensors were categorized according to their location in the z-direction as top (700~1050 μm), middle (350~700 μm) and bottom (0~350 μm). (b,c,d) Spatiotemporal fluorescence change (F/F0) of microgel sensors after an exposure to a 5 mg/ml of collagenase solution on the top of (c) DTT crosslinked PEG hydrogels and (d) KCGPQG↓IWGQCK crosslinked PEG hydrogels and (e) gelatin hydrogels.