Table 2. Association analysis of selected SNPs with Type 2 Diabetes.
Gene | SNP ID | Major/Minor allele | MAF | OR (95% CI)a | P-value |
ADIPOQ | rs266729 | C/G | 0.239 | 1.08 (0.83-1.42) | 0.555 |
ADIPOQ-AS1 | rs1063539 | G/C | 0.111 | 1.03 (0.71-1.48) | 0.889 |
APOE | rs440446 | G/C | 0.375 | 1.16 (0.91-1.48) | 0.224 |
CAT | rs1001179 | G/A | 0.214 | 0.93 (0.7-1.24) | 0.629 |
CLPTM1L | rs401681 | C/T | 0.40 | 1.09 (0.86-1.39) | 0.467 |
DDAH1 | rs13373844 | A/C | 0.334 | 1.09 (0.85-1.40) | 0.496 |
DDAH1 | rs7521189 | A/G | 0.466 | 0.98 (0.60-1.57) | 0.840 |
EPO | rs1617640 | T/G | 0.330 | 1.08 (0.84-1.39) | 0.544 |
EPO | rs507392 | T/C | 0.334 | 1.13 (0.88-1.46) | 0.339 |
EPO | rs551238 | A/C | 0.329 | 1.1 (0.86-1.42) | 0.435 |
FTO | rs1121980 | C/T | 0.477 | 1.01 (0.8-1.27) | 0.928 |
FTO | rs1421085 | T/C | 0.464 | 1.01 (0.8-1.27) | 0.933 |
FTO | rs17817449 | T/G | 0.446 | 1.06 (0.84-1.33) | 0.621 |
FTO | rs1800592 | A/G | 0.249 | 0.85 (0.65-1.11) | 0.221 |
FTO | rs8050136 | C/A | 0.447 | 1.02 (0.81-1.29) | 0.847 |
FTO | rs9939609 | T/A | 0.441 | 1.03 (0.82-1.3) | 0.804 |
HIF1A | rs11549465 | C/T | 0.151 | 1.08 (0.78-1.49) | 0.651 |
IGF2BP2 | rs4402960 | G/T | 0.347 | 1.28 (1.01-1.62) | 0.038 |
IRS1 (500 kb downstream) | rs2943641 | C/T | 0.384 | 1.11 (0.87-1.40) | 0.404 |
KCNJ11 | rs5215 | T/C | 0.341 | 1.01 (0.79-1.28) | 0.963 |
TCF7L2 | rs7903146 | C/T | 0.405 | 1.22 (0.96-1.55) | 0.097 |
TERC | rs12696304 | C/G | 0.266 | 1.06 (0.82-1.36) | 0.680 |
TERT | rs2735940 | T/C | 0.415 | 1.34 (1.05-1.71) | 0.017 |
TERT | rs2736098 | G/A | 0.303 | 0.64 (0.49-0.84) | 0.001 |
TERT | rs2736109 | G/A | 0.423 | 0.79 (0.62-1.01) | 0.061 |
UCP1 | rs3811787 | T/G | 0.255 | 0.85 (0.65-1.11) | 0.225 |
UCP1 | rs45539933 | C/T | 0.063 | 0.99 (0.61-1.6) | 0.969 |
UCP2 | rs660339 | C/T | 0.354 | 0.95 (0.74-1.21) | 0.676 |
UCP3 | rs1800849 | C/T | 0.15 | 0.87 (0.62-1.21) | 0.404 |
VEGFA | rs3025021 | C/T | 0.349 | 0.87 (0.67-1.13) | 0.285 |
Abbreviations: MAF, Minor Allele Frequency; OR, odds ratio; CI, confidence interval.
Significant p-values (<0.05) are highlighted in bold.
a For each SNP an adjusted additive model was considered.