Table 5. Association analysis of candidate SNPs with diabetic microvascular and macrovascular complications.
| Retinopathy | Nephropathy | Ischemic heart disease and stroke | |||||||
| Gene | SNP | Alleles | MAF | OR (95% CI)a | P-value | OR (95% CI)a | P-value | OR (95% CI)a | P-value |
| ADIPOQ | rs266729 | C/G | 0.24 | 1.10 (0.74-1.63) | 0.641 | 1.10 (0.70-1.73) | 0.672 | 0.61 (0.39-0.95) | 0.024 |
| CAT | rs1001179 | G/A | 0.22 | 1.03 (0.66-1.63) | 0.885 | 0.48 (0.26-0.87) | 0.010 | 1.03 (0.66-1.6) | 0.905 |
| FTO | rs1121980 | C/T | 0.48 | 1.01 (0.70-1.44) | 0.976 | 0.64 (0.42-0.96) | 0.030 | 0.97 (0.68-1.38) | 0.875 |
| FTO | rs1421085 | T/C | 0.47 | 0.97 (0.68-1.38) | 0.864 | 0.63 (0.42-0.95) | 0.026 | 0.95 (0.67-1.35) | 0.783 |
| FTO | rs17817449 | T/G | 0.45 | 1.08 (0.76-1.53) | 0.684 | 0.66 (0.44-0.098) | 0.044 | 0.97 (0.69-1.37) | 0.866 |
| UCP1 | rs1800592 | A/G | 0.24 | 0.84 (0.55-1.29) | 0.426 | 0.57 (0.33-0.98) | 0.031 | 1.10 (0.74-1.64) | 0.643 |
| UCP1 | rs3811787 | T/G | 0.25 | 1.20 (0.80-1.79) | 0.382 | 0.57 (0.34-0.98) | 0.031 | 1.20 (0.81-1.77) | 0.367 |
| UCP1 | rs45539933 | C/T | 0.06 | 0.31 (0.12-0.82) | 0.010 | 0.52 (0.18-1.52) | 0.198 | 1.08 (0.52-2.26) | 0.837 |
Abbreviations: MAF, Minor Allele Frequency; OR, odds ratio; CI, confidence interval.
Significant p-values (<0.05) are highlighted in bold.
a For each SNP an adjusted additive model was considered.