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. 2018 Feb 5;10(2):197–211. doi: 10.18632/aging.101376

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Copyright © 2018 Sun et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Autophagy depressed germ cell cyst breakdown and increased the number of surviving gem cells after 3 days of treatment. (A) IF staining for MVH (green) of control, rapamycin and 3-MA treated mouse ovaries for 3 days. (B) Percentage of germ cells in cysts and follicles in the three groups after 3 days treatment. (C) Average number of survived oocytes in the three groups. (D) Level of BECLIN1 protein in control, rapamycin and 3-MA treated ovaries (6 h). The results are presented as mean ± SD. *P < 0.05; **P < 0.01.