Figure 10.

Using the xCELLigence to assess the effects of 2-butene-1,4-bis-TPP on cell proliferation and viability/cell cycle arrest. The xCELLigence system allows the real-time, label-free, monitoring of cell health and behavior, via high frequency measurement of cell-induced electrical impedance. Note that the effects of 2-butene-1,4-bis-TPP are concentration-dependent and most notable after 72 hours, but are also noticeable at 48 hours. Little or no effect was observed after 24 hours of incubation. Interestingly, 2-butene-1,4-bis-TPP was cytostatic at 1 μM.