Table 1. Four ineffective TPP compounds.
Hoechst staining (%) | ATP level (%) | |
mito-TEMPO* | 100.0 | 100.0 |
cyanomethyl-TPP | 97.2 | 95.1 |
4-cyanobenzyl-TPP | 72.7 | 68.2 |
p-xylylene-bis-TPP | 69.1 | 43.9 |
*(2‐(2,2,6,6‐tetramethylpiperidin‐1‐oxyl‐4‐ylamino)‐2‐oxoethyl‐TPP. Cell viability and intracellular ATP levels were determined in the same treated samples. MCF‐7 cell line, 50 μM treatment for 72 hours.