Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
a, Histone modifications (red) are retained locally during replication but diluted by nascent histones (pale yellow). Maintenance can occur via self-propagation or via a de novo modification mechanism. When modifications are erased through genetic knockout of modifier followed by re-expression, only de novo methylation mechanisms are possible.
b, Knockout and rescue strategy to probe de novo methylation capacity.
