Table 1.
Transcription Factor Binding Motifs Identified by Genomatix MatIspector Analysis of Fgf23 −16kb Element
| Detailed matrix information | Strand | Core similarity | Matrix similarity | Sequence |
|---|---|---|---|---|
| Hypoxia‐response elements | – | 1 | 0.985 | tcttggtaCGTGagtgt |
| Binding site of Clock/BMAL1 and NPAS2/BMAL1 heterodimers | + | 1 | 0.983 | aagagtCACGtgtgctc |
| NF‐κB (p65) | – | 1 | 0.974 | ccaggactTTCCttt |
| STAT5 | – | 0.945 | 0.97 | tagaTTCCtagaagtgaaa |
| STAT3 | – | 1 | 0.966 | gctcTTCCagggaagtggt |
| AhR nuclear translocator homodimers | – | 1 | 0.963 | tgagcacaCGTGactct |
| STAT6 | + | 1 | 0.951 | ccacTTCCctggaagagct |
Bioinformatic analysis of the −16kb region using the Genomatix software tool MatInspector reveals the presence of several transcription factor binding motifs associated with inflammatory signaling and corresponding sequences along with highest calculated matrix similarity scores (greater than 0.95).