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. 2017 Mar 27;3(1):39–47. doi: 10.1016/j.bioactmat.2017.03.001

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Scheme 1 — Schematics of RGD functionalized, DOX loaded, fluorescence emitting crosslinked PBPLP nanogels. (Step 1) Photocrosslinkable fluorescent polymer (PBPLP) crosslinked into fluorescent nanogels in the presence of a photo-initiator, acrylic acid, and UV light; (Step 2) PBPLP nanogels can be surface functionalized with biologically active molecules (herein, RGD peptide) using EDC/sulfo-NHS chemistry; (Step 3) Doxorubicin (anti-cancer drug) can be encapsulated within these soft particles to create surface functionalized, fluorescence emitting drug delivery vehicles.