. 2017 Sep 6;6(6):740–754. doi: 10.1039/c7tx00223h

Table 1. Detection of oxidative DNA damage by o-quinones.

Quinone	Treatment conditions	Lesion Type	Method of Detection	Reference
4-OHEN	4-OHEN + Sprague-Dawley rat mammary gland	DNA strand scission	Comet assay	Zhang et al.40
4-OHEN	4-OHEN + Sprague-Dawley rat mammary gland	8-Oxo-dG and 8-oxo-dA	SID-LC/MS/MS	Zhang et al.40
4-OHEN	4-OHEN + S30 human breast cancer cells	8-Oxo-dG	SID-LC/MS/MS and Comet assay coupled with Fpg	Wang et al.47
4-OHEN	4-OHEN + Calf thymus DNA + NADPH + CuCl₂	8-Oxo-dG and apurinic sites/apyridiminic sites	SID-LC/MS/MS and aldehyde reactive probe	Wang et al.47
BPQ	BPQ + NADPH + CuCl₂ + poly-dG:poly-dC or phage DNA	DNA strand scission	Electrophoresis	Flowers et al.45
BPQ	BPQ + NADPH + CuCl₂ + calf thymus DNA	Apurinic sites/apyridiminic sites	Aldehyde reactive probe	Park et al.41
BPQ	BPQ + NADPH + CuCl₂ + calf thymus DNA	8-Oxo-dG	EC-HPLC	Park et al.41
BAQ	BAQ+ NADPH + CuCl₂ + calf thymus DNA	Apurinic sites/apyridiminic sites	Aldehyde reactive probe	Park et al.41
BAQ	BAQ+ NADPH + CuCl₂ + calf thymus DNA	8-Oxo-dG	EC-HPLC	Seike et al.58
DMBAQ	DMBAQ + NADPH + CuCl₂ + calf thymus DNA	Apurinic sites/apyridiminic sites	Aldehyde reactive probe	Park et al.41
DMBAQ	DMBAQ + NADPH + CuCl₂ + calf thymus DNA	8-Oxo-dG	EC-HPLC
BPQ	BPQ + NADPH + CuCl₂ + p53 plasmid DNA	8-Oxo-dG	EC-HPLC	Park et al.49
BAQ	BAQ + NADPH + CuCl₂ + p53 plasmid DNA	8-Oxo-dG	EC-HPLC	Park et al.49
DMBAQ	DMBAQ + NADPH + CuCl₂ + p53 plasmid DNA	8-Oxo-dG	EC-HPLC	Park et al.49
BPQ	BPQ + H358 human lung epithelial cells	8-Oxo-dG	SID-LC/MS/MS	Mangal et al.82
BPQ	BPQ + H358 human lung epithelial cells	8-Oxo-dG	Comet assay coupled to OGG1	Mangal et al.82
BPQ	B[a]P-7,8-trans-dihydrodiol + A549 cells ± COMT inhibitor	8-Oxo-dG	SID-LC/MS/MS	Park et al.96
BPQ	B[a]P-7,8-trans-dihydrodiol + A549 cells ± COMT inhibitor	8-Oxo-dG	Comet assay coupled to OGG1	Park et al.96