TABLE 3.
Programmatic, patient-related and clinical variables associated with virological failure at an antiretroviral clinic in eThekwini Health District, 2011 to 2014.
| Factor | RR (95% CI) | p | Adjusted RR (95% CI) | p |
|---|---|---|---|---|
| Gender (females) | 0.8 (0.5–1.4) | 0.47 | 0.08 (< 0.01–404) | 0.56 |
| Age range (years) | - | - | - | - |
| 18–29 | 1.5 (0.6–4.1) | 0.37 | 1.9 (0.6–6.2) | 0.24 |
| 30–39 | 0.8 (0.3–2.1) | 0.64 | 0.9 (0.3–2.7) | 0.87 |
| 40–49 | 0.9 (0.3–2.4) | 0.86 | 0.9 (0.3–2.7) | 0.85 |
| Viral load at switch | 1.1 (0.9–1.3) | 0.45 | 1.1 (0.8–1.7) | 0.53 |
| History of TB | 0.9 (0.6–1.6) | 0.84 | 0.8 (0.5–1.4) | 0.40 |
| Pregnancy | 1.0 (0.9–1.1) | 0.49 | 0.9 (0.3–2.9) | 0.92 |
| Regimen modification prior to switch | 0.9 (0.5–2.1) | 0.93 | 0.9 (0.4–2.0) | 0.83 |
| First-line regimen | - | - | - | - |
| Exposure to EFV-based first-line regimen | 1.3 (0.8–2.3) | 0.29 | 1.4 (0.8–2.5) | 0.28 |
| Delays of greater than six months | 1.7 (0.8–3.8) | 0.18 | 1.6 (0.7–3.5) | 0.26 |
| Patients defaulted appointment | 1.9 (1.1–3.2) | 0.02 | 1.5 (0.9–2.7) | 0.11 |
TB, tuberculosis; EFV, efavirenz.