Table 2.

The univariate and multivariate analyses of the prognostic factors

Factors	Univariate analysis			Multivariate analysis
	HR	95% CI	P-value	HR	95% CI	P-value
Age (years)
≥65 vs <65	1.042	0.672–1.329	0.617
Gender
Male vs female	0.945	0.583–1.242	0.429
Tumor size (cm)						0.019
>4 vs ≤4	2.406	1.579–3.938	0.001	2.077	1.354–3.176
Perineural invasion						0.247
Present vs absent	3.172	1.966–5.319	0.02	1.89	0.754–2.763
Clinical stage						0.029
Advanced stage vs early stage	2.676	1.431–3.599	<0.001	1.917	1.368–2.725
Distant metastasis						0.193
Yes vs no	1.701	1.288–3.574	0.015	1.179	0.885–2.719
Differentiation
Well vs moderate vs poor	1.136	0.659–1.946	0.313
LRP16 expression						0.011
Positive vs negative	2.725	1.403–3.879	<0.001	1.635	1.291–2.504