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. 2018 Mar 5;11:1245–1258. doi: 10.2147/OTT.S152613

Figure 1.

Figure 1

Icotinib hydrochloride enhances cisplatin- or radiation-induced proliferation inhibition in Hela S3 cells.

Notes: (A and B) Viability of Hela S3 cells was measured by CCK-8 assay 24 hours after various doses of irradiation (A) or cisplatin (B) treatment following preincubation with different concentrations of IH for 2 hours. (C and D) Cell proliferation of Hela S3 cells in the following 72 hours after being treated with 5 μM IH plus 6 Gy radiation (C) or 2 μg/mL cisplatin (D). Error bars, SD. *P<0.05, **P<0.01, and ***P<0.001 by two-tailed Student’s t-test; n=3 independent cell cultures.

Abbreviations: Ctrl, control; IH, icotinib hydrochloride; IR, ionizing radiation; Cis, cisplatin; CCK-8, Cell Counting Kit-8; h, hours.