TABLE 5.

Management of an individual exposed to an HBsAg-positive or unknown source.

Vaccinated status of exposed	HBV vaccine	HBIG (0.06 mL/kg)	HBsAb
Previous vaccination; known responder	None	None	Not done
Not vaccinated	1st dose stat and proceed to accelerated schedule	If HBsAb < 10 IU/mL, give stat HBIG and repeat at 1 month	If HBsAb > 10 IU/mL, no treatment
	(0, 1 and 6 months)
Incomplete vaccination or unsure	Complete depending on documentation, or restart	Single dose stat	-
	0, 1 and 6 months
Vaccinated; unknown response	Single booster stat
Non-responder to prior vaccination	1st dose stat and proceed to accelerated schedule	1 dose stat, repeat after 1 month	HBsAb < 10 IU/mL
	0, 1 and 6 months
Previously vaccinated with four doses or two completed vaccine series; non-responder	Consider alternative vaccine	-	-

Comment: HBIG and HBV vaccine can be administered concomitantly at different sites.

HBV, hepatitis B virus; HIV, human immunodeficiency virus; HBIG, hepatitis B immunoglobulin; HBsAb, hepatitis B surface antibody.