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. 2018 Mar 8;13(3):e0193649. doi: 10.1371/journal.pone.0193649

Table 1. Pathways differentially affected by each set of stimulation.

Pathways affected by palmitate+LPS vs LPS Up-regulated genes Down-regulated genes p
None - -
Pathways affected by mmLDL+LPS vs LPS Up-regulated genes Down-regulated genes p
Cytokine-cytokine receptor interaction Csf3, Il1R2, Csf2, Il-6, Pdgfb, Il4Ra, Cxcl2, Il17Ra, Osm, Tnfrsf9, Il23A, Il-1β, Il-1α Cd40, Il15, Kitl, Cxcl10, Ccl12, Tnfsf10 1.48E-06
Hematopoietic cell lineage Csf3, Il1R2, Csf2, Il-6, Il4Ra, Il-1β, Il-1α Itga4, Kitl 2.65E-04
Jak-STAT signaling pathway Osm, Csf3, Csf2, Il-6, Il23A, Socs3, Il4Ra Tyk2, Il15, Stat1 3.45E-03
Toll-like receptor signaling pathway Fos, Il-6, Il-1β Tlr3, Cd40, Stat1, Tlr7, Cxcl10 3.69E-03
Axon guidance Rnd1, Kras, Sema4C, Epha2 Sema5a, Epha4, Plxnc1, Nrp1, Sema6d 4.80E-03
Hypertrophic cardiomyopathy (HCM) Actg1, Tnnt2, Itga9, Il-6, Itgav, Lmna Itga4 6.77E-03
Arrhythmogenic right ventricular cardiomyopathy (ARVC) Actg1, Itga9, Itgav, Lmna, Gja1 Itga4 1.74E-02
MAPK signaling pathway Dusp5, Il1R2, Fos, Map4K4, Map3K5, Kras, Pdgfb, Nr4A1, Il-1β, Gadd45A, Il-1α, Dusp6 - 1.76E-02
NOD-like receptor signaling pathway Il-6, Cxcl2, Il-1β, Nlrp3 Ccl12 3.60E-02
Dilated cardiomyopathy Actg1, Tnnt2, Itga9, Itgav, Lmna Itga4 3.79E-02
Focal adhesion Actg1, Itga9, Pdgfb, Itgav, Zyx, Capn2, Thbs1, Pxn Itga4 4.64E-02
Pathways affecte by palmitate+mmLDL+ LPS vs LPS Up-regulated genes Down-regulated genes p
Cytokine-cytokine receptor interaction Csf3, Csf2, Il6, Ccl2, Pdgfb, Ccr1, Cxcl2, Il4ra, Ccl7, Il17ra, Osm, Inhba, Tnfrsf9, Tnfrsf1b, Il23a, Ccr5, Il1b, Il1a Cxcl10 4.32E-07
Hematopoietic cell lineage Csf3, Csf2, Il6, Il4ra, Il1b, Il1a, Itgam H2-Eb1, H2-Aa, Itga4 2.23E-05
Terpenoid backbone biosynthesis - Hmgcr, Fdps, Hmgcs1, Acat2, Idi1 9.91E-05
Graft-versus-host disease Il6, Cd80, Il1b, Il1a H2-Eb1, H2-Aa 4.29E-03
NOD-like receptor signaling pathway Il6, Ccl2, Cxcl2, Il1b, Nlrp3, Ccl7, - 5.72E-03
Cell adhesion molecules (CAMs) Itgal, Siglec1, Cd80, Itgav, Itgam Icam1, H2-Eb1, H2-Aa, Itga4 7.74E-03
Axon guidance Rnd1, Kras, Sema4c, Epha2 Sema5a, Epha4, Plxnc1, Sema6d 1.08E-02
Intestinal immune network for IgA production Il6, Cd80, H2-Eb1, H2-Aa, Itga4 1.77E-02
Hypertrophic cardiomyopathy (HCM) Actg1, Tnnt2, Il6, Itgav, lmna Itga4 1.98E-02
Chemokine signaling pathway Kras, Ccl2, Ccr5, Fgr, Ccr1, Cxcl2, Pxn, Ccl7 Cxcl10 1.98E-02
Type I diabetes mellitus Cd80, Il1b, Il1a H2-Eb1, H2-Aa 2.94E-02
Viral myocarditis Actg1, Itgal, Cd80 Icam1, H2-Eb1, H2-Aa 3.04E-02
Toll-like receptor signaling pathway Fos, Il6, Cd80, Il1b, Tlr8 Cxcl10 3.69E-02