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A dual antinucleosome monoclonal antibody and TAT peptide targeted MMP-2-responsive multifunctional liposomal delivery system is designed. Upon nanocarrier accumulation in tumors and specific targeting of cancer cells, in response to up-regulated extracellular MMP-2 in tumors, the hidden surface-attached TAT peptides expose and enhance cellular internalization of liposomes. Reprinted from reference (215) Copyright 2012, with permission from American Chemical Society
