Table 2. Results from simulations with Ovol regulation can recapitulate the epidermal phenotypes of all mutants.
The model details and parameter values are shown in S1 Text.
| Model 1 | WT | Ovol1-/- | Ovol2 SSKO | Ovol2 BT | Ovol DKO | |||||
| K14+ basal layer | 1.60 | — | 1.87 | — | 1.72 | — | 1.13 | — | 4.06 | ↑ |
| K1+ spinous layer | 8.18 | — | 17.50 | ↑ | 8.37 | — | 3.08 | ↓ | 169.14 | ↑ |
| Lor+ granular layer | 4.11 | — | 4.56 | — | 4.38 | — | 3.07 | ↓ | 1.55 | ↓ |
| Ovol1 (α) | a = 1 | 0 | d = 1.6 | g = 0.5 | 0 | |||||
| Ovol2 (β) | b = 1 | c = 1.25 | 0 | h = 10 | 0 | |||||
| Model 2 | WT | Ovol1-/- | Ovol2 SSKO | Ovol2 BT | Ovol DKO | |||||
| K14+ basal layer | 2.81 | — | 2.90 | — | 2.85 | — | 2.59 | — | 3.35 | ↑ |
| K1+ spinous layer | 13.37 | — | 25.78 | ↑ | 13.17 | — | 4.27 | ↓ | 174.80 | ↑ |
| Lor+ granular layer | 6.57 | — | 6.59 | — | 6.75 | — | 5.80 | ↓ | 1.61 | ↓ |
| Ovol1 (α) | a = 1 | 0 | d = 1.6 | g = 0.5 | 0 | |||||
| Ovol2 (β) | b = 1 | c = 1.25 | 0 | h = 50 | 0 | |||||