. 2018 Feb 26;14(2):e1006006. doi: 10.1371/journal.pcbi.1006006

Table 3. 3D simulation results with Ovol down-regulation of v₀ and p₀ and up-regulation of d₂ can recapitulate the epidermal phenotypes of all mutants, in cell number wise.

Mean and standard deviation of the cell number in 3D model is over an ensemble of 20 simulations. The model details and parameter values are shown in S2 Text.

Model		WT	Ovol1^-/-		Ovol2 SSKO		Ovol2 BT		Ovol DKO
3D hybrid	C₀	285±34	305±32	—	280±39	—	277±36	—	330±24	↑^*
	C₁+C₂	1199±178	4973±539	↑^**	1086±136	—	706±96	↓^**	21256±1262	↑^**
	C₃	748±92	680±51	—	816±83	—	620±66	↓^*	122±18	↓^**

* represents p-value<0.005 for t-test

** represents p-value<0.00001.

Table 3. 3D simulation results with Ovol down-regulation of v0 and p0 and up-regulation of d2 can recapitulate the epidermal phenotypes of all mutants, in cell number wise.

Table 3. 3D simulation results with Ovol down-regulation of v₀ and p₀ and up-regulation of d₂ can recapitulate the epidermal phenotypes of all mutants, in cell number wise.