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. 2018 Feb 26;14(2):e1006934. doi: 10.1371/journal.ppat.1006934

Fig 5. HMAb 3F9 use an epitope contained within EDI.

Fig 5

(A) rDENV2/4-EDI/II is DENV2 virus containing EDI/II hinge region residues from DENV4. rDENV2/4-EDI is DENV2 virus containing EDI residues from DENV4. 3F9 was assessed for its ability to bind (B and E) and neutralize (C and F) recombinant DENVs in ELISA binding assays and Focus Reduction Neutralization Tests (FRNT) in Vero-81 cells (C) or C6/36 cells (F). Dotted line in ELISA represents the background signal. (D) rDENV4/2-EDI is DENV4 virus containing EDI residues from DENV2.