Fig 10. Ki values of the selected ANPs for HGPRT-I, HGPRT-II and HGXPRT and a comparison of the in vitro antitrypanosomal activity of their prodrugs against T. brucei BF427 cell line with their cytotoxicity in human cell lines.
*Estimated selectivity index (SI) = average CC50 for A549 (Human lung carcinoma cells) divided by the average EC50 for T. brucei BF427 cell line. Synthesis of ANP inhibitors and their prodrugs is described in [20, 22, 28 and 29].aData from [29]; bData from [28]; cData from [20]; dData from [22].