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. 2018 Feb 28;52(4):1224–1234. doi: 10.3892/ijo.2018.4289

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Zinc finger protein 451 (ZNF451) expression in pancreatic ductal adenocarcinoma (PDAC) tumor tissues and cell lines inversely correlates with BC032020 expression. (A) The genomic context and locations of BC032020 and ZNF451 are shown. (B) ZNF451 mRNA levels in PDAC tumor tissues and adjacent tissues. (C) Correlation between BC032020 and ZNF451 expression in PDAC tumor tissues. (D) ZNF451 expression in PDAC tumor tissues and adjacent non-tumor tissues was detected by immunohistochemistry (×200 magnification). (E and F) Expression levels of BC032020 and ZNF451 in PDAC cells (AsPC-1, BxPC-3, PANC-1, CFPAC-1 and MIA PaCa-2) and human pancreatic ductal epithelial (HPDE) cells were evaluated by RT-qPCR. (G) Correlation between BC032020 and ZNF451 expression in the PDAC cell lines. (H) Protein levels of ZNF451 in PDAC cells and HPDE cells were evaluated by western blot analysis. The relative expression levels were normalized to those of GAPDH. Data represent the means ± SD of values obtained from triplicate samples. ^*P<0.05, ^**P<0.01, ^***P<0.001 vs. HPDE cells.