Table V.

Risk factors for predicting postoperative recurrence and cancer-specific survival in ccRCC using the ISUP grading system.

Factors	Recurrence-free survival			Cancer-specific survival
	Univariate	Multivariate		Univariate	Multivariate
	P-value	HR (95% CI)	P-value	P-value	HR (95% CI)	P-value
Age (years)	0.0246		0.0630	0.0018		0.0327
≤62
>62		1.77 (0.98–3.28)			3.91 (1.27–17.0)
Sex	0.5708			0.4909
Female
Male
pT stage	<0.0001		0.4095	<0.0001		0.8970
≤pT2
≥pT3		1.41 (0.63–3.26)			1.09 (0.32–4.33)
ISUP grade	<0.0001		0.8596	<0.0001		0.0355
1/2
3/4		1.07 (0.53–2.19)			9.31 (1.73–172)
TN	<0.0001		<0.0001	<0.0001		0.0003
Absence
Presence		8.01 (3.91–16.5)			8.56 (2.80–29.9)
MVI	<0.0001		0.0057	<0.0001		0.2185
Absence
Presence		2.97 (1.33–6.30)			2.32 (0.56–8.67)

ccRCC, clear cell renal cell carcinoma; ISUP, International Society of Urological Pathology; TN, tumor necrosis; MVI, microvascular invasion; HR, hazard ratio; CI, confidence interval.