Table 2.
Clinical characteristics of patients with idiopathic pulmonary fibrosis with acute exacerbation according to the ATS criteria
| Parameters | Triggered (n=12) Mean±SD | Idiopathic (n=53) Mean±SD | p |
|---|---|---|---|
| Age (years) | 77.1±8.4 | 74.2±11.8 | 0.214 |
| Gender (male/female) | 8/4 | 32/21 | 0.654 |
| Pack-year (years) | 49.3±51.3 | 28.5±37.3 | 0.056 |
| mMRC | 3.2±1.1 | 2.7±0.9 | 0.075 |
| Dyspnea duration (days) | 4.4±3.7 | 7.0±6.1 | 0.918 |
| Clubbing (%) | 42 | 26 | 0.151 |
| WBC (mm3) | 11,008±5116 | 11.450±5468 | 0.601 |
| CRP (mg/dL) | 8.2±6.5 | 8.2±7.5 | 0.504 |
| LDH (IU/l) | 410±153 | 389±144 | 0.332 |
| KL-6 (IU/l) | 2825±2354 | 1700±1502 | 0.024 |
| Survival time (months) | 1.4±0.4 | 11.4±3.6 | 0.094 |
| Imaging findings | |||
| Traction bronchiectasis | 2.3±0.7 | 2.3±0.1 | 0.395 |
| Honeycombing | 1.4±0.5 | 1.7±0.7 | 0.858 |
| GGO+consolidation | 7.3±6.7 | 4.2±3.3 | 0.010 |
| Total extent | 11.1±10.7 | 8.5±5.2 | 0.005 |
mMRC: modified Medical Research Council; WBC: white blood cell; CRP: C-reactive protein; LDH: lactate dehydrogenase; KL-6: Krebs von den Lungen-6; ATS: American Thoracic Society; GGO: ground-glass opacity