Table 2.
Current clinical trials for lupus erythematosus treatment.
| Treatment | Condition(s) | Phase | Enrollment | Start | Completion |
|---|---|---|---|---|---|
| Biologics | |||||
|
| |||||
| ALX-0061 (anti-IL-6R) | SLE | 2 | 300 | Jul ’15 | Mar ’18 |
| Anifrolumab (anti-IFNAR1) | SLE | 3 | 360 | Jul ’15 | Oct ’18 |
| BIIB059 (anti-BDCA-2) | SLE | 1 | 108 | Apr ’14 | Jun ’16 |
| Brentuximab vedotin (anti-CD30) | SLE | 2 | 40 | Jul ’15 | Apr ’17 |
| BT063 (anti-IL-10) | SLE | 2 | 36 | Aug ’15 | Aug ’17 |
| Lulizumab pegol (anti-CD28) | SLE | 2 | 350 | Nov ’14 | Mar ’17 |
| Milatuzumab (anti-CD74) | CLE, DLE, SLE | 1–2 | 30 | Jan ’15 | Jan ’17 |
| Omalizumab (anti-IgE) | SLE | 1 | 30 | Oct ’12 | Jul ’20 |
| SAR113244 (anti-CCR5) | SLE | 1 | 24 | Jul ’15 | Sep ’16 |
| Ustekinumab (anti-IL-12, -23) | SLE | 2 | 100 | Oct ’15 | Dec ’17 |
|
| |||||
| Fusion Proteins | |||||
|
| |||||
| Atacicept (TACI:Fc5) | SLE | 2 | 306 | Dec ’13 | Mar ’16 |
| Etanercept (TNFR:Fc) | CCLE, CLE, DLE | 2 | 25 | Feb ’16 | Aug ’17 |
| RSLV-132 (RNase:Fc) | SLE | 2 | 50 | Jan ’16 | Jun ’17 |
|
| |||||
| Immunomodulators | |||||
|
| |||||
| AMG 570 | SLE | 1 | 40 | Mar ’16 | Apr ’17 |
| CC-220 | SLE | 2 | 140 | Sep ’14 | Aug ’16 |
| Cenerimod | SLE | 1–2 | 64 | Jun ’15 | Jan ’17 |
|
| |||||
| Other | |||||
|
| |||||
| Allogeneic mesenchymal stem cells | SLE | 2 | 81 | Jul ’16 | Jun ’21 |
| Amiselimod (immunosuppressant) | SLE | 1 | 18 | Feb ’15 | Jan ’17 |
| Autologous EBV-specific cytotoxic T cells | SLE | 1–2 | 10 | Jan ’16 | Jan ’19 |
| Autologous polyclonal Tregs | CLE, DLE, SLE | 1 | 18 | Jul ’15 | Dec ’17 |
| Bortezomib (proteosome inhibitor) | SLE | 2 | 18 | Oct ’14 | Dec ’16 |
| Dipyridamole | SLE | Unavailable | 50 | Feb ’13 | Feb ’16 |
| IL-2 | SLE | 2 | 132 | Jan ’14 | Jan ’16 |
| MSC2364447C (Btk inhibitor) | SLE | 1 | 24 | Nov ’15 | Sep ’16 |
| Nelfinavir | SLE | 2 | 43 | Sep ’14 | Dec ’16 |
| Rigerimod (T cell inhibitor) | SLE | 3 | 200 | Dec ’15 | Jun ’17 |
| Tofacitinib (JAK inhibitor) | SLE | 1 | 38 | Aug ’15 | May ’20 |
| UVA1 radiation | CLE | Unavailable | 15 | Sep ’12 | Sep ’17 |
SLE = systemic lupus erythematosus; CLE = cutaneous lupus erythematosus; DLE = discoid lupus erythematosus; CCLE = chronic cutaneous lupus erythematosus