Table 2.

Toxicities of quinacrine, hydroxychloroquine, and chloroquine

		Quinacrine N (%)	HCQ * N (%)	CQ ** N (%)
Total		43	101	30
Skin
Dyschromia		8 (18.6)	2 (2.0)	0
Pruritic Rash		11 (25.6)	36 (35.6)	7 (23.4)
Bullous Rash		0	2 (2.0)	0
CLE exacerbation		0	1 (1.0)	0
Alopecia		0	5 (5.0)	3 (10.0)
Gastrointestinal
N / V / D / C a		8 (18.6)	20 (19.8)	6 (20.0)
Transaminitis		2 (4.7) b	1 (1.0)	0
Dysgeusia		2 (4.7)	0	1 (3.4)
Neurologic
Headache / Dizziness		3 (7.0)	10 (9.9)	1 (3.4)
Tinnitus		1 (2.3)	2 (2.0)	0
Hearing Loss		0	1 (1.0)	0
Insomnia		1 (2.3)	0	1 (3.4)
Anxiety		1 (2.3)	0	0
Mental Fog		1 (2.3)	3 (3.0)	1 (3.4)
Auditory Hallucinations		0	1 (1.0) g	0
Nightmares		0	1 (1.0)	0
Ocular		0	18 (17.8)	10 (33.4)
Musculoskeletal
Myopathy		1 (2.3)	1 (1.0)	0
Muscle Cramps		0	1 (1.0)	0
Joint Pains		0	1 (1.0)	0
Shakes / Tremors		0	1 (1.0)	0
Hematologic / Oncologic
Thrombocytopenia		1 (2.3) c	0	0
Leukopenia		1 (2.3) d	0	0
Pancytopenia		1 (2.3) e	0	0
Other
Hypersensitivity		1 (2.3) f	0	0
Lethargy/Fatigue		4 (9.3)	1 (1.0)	1 (3.4)
Weight Gain		0	1 (1.0)	0
Palpitations		0	1 (1.0)	0

^aNausea / Vomiting / Diarrhea / Constipation

^bTransaminitis was mild. Lab values are available for one case: AST 47 ALT 85

^cLab values unclear from records

^dIn setting of lupus flare in patient with SLE-related leukopenia; unclear if drug induced

^eIn the setting of evolving MDS. WBC 2.9, Hematocrit 31.7, Platelets 130K

^fDyspnea, body cramping, fatigue, methemoglobinemia; similar reaction on dapsone

^gRelated to supratherapeutic plaquenil dose

^*HCQ = Hydroxychloroquine;

^**CQ = Chloroquine