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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Bioessays. 2017 Dec 13;40(1):10.1002/bies.201700170. doi: 10.1002/bies.201700170

Figure 2.

Figure 2

Model for UPF1’s role in myogenesis. In myoblasts, UPF1 levels are high allowing UPF1 to degrade the MYOG mRNA [13] through its NMD activity, and to degrade MYOD protein through its E3 ubiquitin ligase activity [19]. UPF1’s negative effect on MYOD protein and MYOG mRNA levels correlates with the low levels of these factors in myoblasts and allows UPF1 to suppress myogenesis. When myoblasts differentiate into myotubes, UPF1 levels drop, which may allow MYOG mRNA and MYOD protein to escape degradation, correlating with the high levels of these factors seen in differentiated muscle cells (myotubes).