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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: J Endocrinol. 2018 Feb 12;237(1):R19–R34. doi: 10.1530/JOE-17-0708

Figure 4.

Figure 4

Model for localization of TRα1 isoforms to the mitochondria, plasma membrane, and nucleus. TRα1 mRNA yields different forms of truncated TR by internal translation initiation. Once synthesized in the cytosol, the different forms localize to different intracellular compartments. TRα1 p28 and TRα1 p43 localize to the mitochondrial inner membrane and matrix, respectively. TRα1 p30 localizes to the inner surface of the plasma membrane, where it can bind to thyroid hormone to mediate thyroid hormone signaling. The specific localization and function of TRα1 p33 remains unknown. Full-length TRα1 (TRα1 p46) localizes to the nucleus where it modulates target gene expression in response to thyroid hormone, in association with corepressors and coactivators. Thyroid hormone enters the cell through the monocarboxylate 8 and 10 transporters (MCT8/10).