Table 1.
Participant characteristics and clinical laboratory values.
| Variable | Controls | CF | P value |
|---|---|---|---|
| Demographics | |||
|
| |||
| N | 14 | 14 | |
| Sex (M/F) | 6/8 | 6/8 | |
| Age (y) | 14 ± 3 | 14 ± 3 | 0.905 |
| Height (cm) | 158 ± 18 | 156 ± 17 | 0.784 |
| Weight (kg) | 49.7 ± 13.8 | 46.9 ± 14.3 | 0.597 |
| BMI (kg/m2) | 19.7 ± 2.9 | 18.7 ± 2.0 | 0.333 |
| Body Fat (%) | 23.7 ± 8.4 | 19.8 ± 6.0 | 0.177 |
| SBP (mm Hg) | 107 ± 16 | 104 ± 12 | 0.553 |
| DBP (mm Hg) | 63 ± 9 | 61 ± 6 | 0.452 |
| Resting O2 Saturation (%) | 98.8 ± 0.4 | 98.2 ± 0.7 | 0.035 |
|
| |||
| Pulmonary Function | |||
|
| |||
| FVC (L) | 3.80 ± 1.27 | 3.58 ± 1.42 | 0.668 |
| FEV1 (L) | 3.36 ± 1.08 | 2.91 ± 1.29 | 0.339 |
| FEV1 (% predicted) | 104 ± 12 | 93 ± 16 | 0.038 |
| FEV1/FVC (%) | 89 ± 7 | 80 ± 7 | 0.004 |
| FEF25–75 (L/s) | 4.0 ± 1.5 | 2.9 ± 1.4 | 0.044 |
|
| |||
| Exercise Capacity | |||
|
| |||
| VO2 peak (ml/kg/min) | 36.4 ± 8.9 | 33.0 ± 6.2 | 0.252 |
| VO2 peak (ml/kg−FFM/min) | 50.4 ± 7.6 | 43.7 ± 6.8 | 0.022 |
| VO2 peak (% predicted) | 85 ± 16 | 74 ± 12 | 0.054 |
| Peak Work (W) | 149 ± 56 | 122 ± 44 | 0.165 |
|
| |||
| Clinical Laboratory Markers | |||
|
| |||
| TC (mg/dL) | 149 ± 27 | 122 ± 25 | 0.013 |
| HDL (mg/dL) | 54 ±11 | 36 ± 13 | 0.001 |
| LDL (mg/dL) | 83 ± 20 | 69 ± 20 | 0.119 |
| Triglycerides (mg/dL) | 71 ± 27 | 82 ± 31 | 0.351 |
| Glucose (mg/dL) | 85 ± 8 | 91 ± 11 | 0.149 |
| TC:HDL | 2.8 ± 0.6 | 3.8 ± 1.8 | 0.072 |
| hsCRP (mg/L) | 0.4 ± 0.2 | 1.6 ± 1.8 | 0.032 |
| Hemoglobin (g/dL) | 13.9 ± 1.4 | 13.5 ± 1.3 | 0.372 |
| Hematocrit (%) | 41.0 ± 4.1 | 40.5 ± 3.1 | 0.766 |
Values are mean ± SD.
Bold face indicates significance.
BMI = body mass index; SBP = systolic blood pressure; DBP = diastolic blood pressure; FVC = forced vital capacity; FEV1 = forced expiratory volume in 1 second; FEF = forced expiratory flow; VO2 = volume of oxygen consumed; TC = total cholesterol; HDL = high density lipoprotein; LDL = low density lipoprotein; hsCRP = high sensitivity C-reactive protein.