Errors in estimation of Cho/H2O in (a) WM and (b) GM averaged across spatial smoothing levels using sDec, M-Int, vAvg, and vReg methods in simulation data with noise comparable to in vivo data. Significant differences using two-sample t-test with p<0.05, p<0.01, and p<0.001 are denoted by *, **, and ***, respectively.