Table 2.

Measures of Cho/Cr calculated in lobar WM and GM, thalamus, and putamen using sDec, M-Int, vAvg, and vReg methods. The percent absolute differences calculated using M-Int, vAvg, and vReg methods as compared to sDec methods are also shown. Significant differences from the sDec method are shown with asterisks with FDR corrected p<0.05, p<0.01, and p<0.001 denoted by *, **, and ***, respectively. Results are shown for the right and left frontal (RF and LF), temporal (RT and LT), parietal (RP and LP), and occipital (RO and LO) lobes, and the cerebellum (C).

WM	Cho/Cr (Mean ± Std. Dev.)				% Absolute Difference from sDec
Region	sDec	M-Int	vAvg	vReg	M-Int	vAvg	vReg
RF	0.302 ± 0.031	0.299 ± 0.031	0.309 ± 0.035	0.313 ± 0.036	1.151	2.120	3.324 (*)
LF	0.298 ± 0.032	0.295 ± 0.031	0.306 ± 0.036	0.31 ± 0.037	0.891	2.664 (*)	3.982 (**)
RT	0.309 ± 0.034	0.301 ± 0.033	0.318 ± 0.034	0.319 ± 0.036	2.703	3.088 (*)	3.108 (*)
LT	0.288 ± 0.031	0.284 ± 0.031	0.3 ± 0.03	0.297 ± 0.033	1.511	4.378 (***)	3.124 (*)
RP	0.285 ± 0.032	0.282 ± 0.031	0.295 ± 0.033	0.303 ± 0.036	1.081	3.382 (**)	6.257 (***)
LP	0.282 ± 0.03	0.279 ± 0.029	0.289 ± 0.03	0.301 ± 0.034	0.958	2.438 (*)	6.764 (***)
RO	0.215 ± 0.03	0.215 ± 0.027	0.222 ± 0.028	0.224 ± 0.031	0.084	3.479 (*)	4.32 (**)
LO	0.216 ± 0.031	0.213 ± 0.028	0.229 ± 0.029	0.225 ± 0.035	1.444	6.21 (***)	4.261 (*)
C	0.279 ± 0.065	0.298 ± 0.052	0.309 ± 0.049	0.281 ± 0.055	6.806	10.745 (***)	0.896
GM	Cho/Cr (Mean ± Std. Dev.)				% Absolute Difference from sDec
Region	sDec	M-Int	vAvg	vReg	M-Int	vAvg	vReg
RF	0.197 ± 0.027	0.269 ± 0.04	0.262 ± 0.037	0.214 ± 0.031	36.499 (***)	32.823 (***)	8.556 (***)
LF	0.193 ± 0.027	0.254 ± 0.044	0.256 ± 0.039	0.228 ± 0.032	31.54 (***)	32.345 (***)	18.224 (***)
RT	0.162 ± 0.025	0.223 ± 0.067	0.215 ± 0.042	0.139 ± 0.025	37.699 (***)	33.023 (***)	14.306 (***)
LT	0.161 ± 0.028	0.232 ± 0.045	0.229 ± 0.045	0.176 ± 0.025	44.576 (***)	42.361 (***)	9.529 (***)
RP	0.135 ± 0.024	0.181 ± 0.024	0.181 ± 0.024	0.146 ± 0.028	34.512 (***)	34.526 (***)	8.164 (***)
LP	0.137 ± 0.023	0.182 ± 0.028	0.185 ± 0.025	0.163 ± 0.024	32.376 (***)	34.852 (***)	18.845 (***)
RO	0.122 ± 0.025	0.176 ± 0.04	0.167 ± 0.025	0.124 ± 0.023	43.925 (***)	36.083 (***)	1.158
LO	0.134 ± 0.024	0.176 ± 0.026	0.172 ± 0.025	0.15 ± 0.024	31.097 (***)	27.697 (***)	11.791 (***)
C	0.179 ± 0.03	0.213 ± 0.037	0.196 ± 0.036	0.172 ± 0.026	19.597 (***)	9.97 (***)	3.685 (*)
	Cho/Cr (Mean ± Std. Dev.)				% Absolute Difference from sDec
Region	sDec	M-Int	vAvg		M-Int	vAvg	vReg
Thalamus	0.289 ± 0.034	0.291 ± 0.033	0.303 ± 0.037		0.567	4.813 (***)	4.798 (***)
Putamen	0.263 ± 0.033	0.266 ± 0.031	0.267 ± 0.032		1.223	1.847	1.598