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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Hypertension. 2018 Feb 26;71(4):752–760. doi: 10.1161/HYPERTENSIONAHA.117.10213

Figure 5. Expression of a miRNA-resistant form of Me1 abrogates cocaine-induced ROS elevation in mouse aortic SMCs.

Figure 5

(A) Transduction of SMCs with lentiviral vectors expressing Me1 lacking the 3’UTR (Me1-del 3’UTR) overcame the inhibitory effect of exogenous miR-30c-5p or cocaine treatment on Me1 expression. (B-C) Unlike vector Ctr-transduced cells, Me1-del 3’UTR-transduced SMCs showed decreased levels of prostaglandin and nitrotyrosine, and that were unchanged by miR-30c-5p overexpression or cocaine treatment. (*: p < 0.05 vs. vector Ctr alone; #: p < 0.05 vs. Me1-del 3’UTR alone).