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. Author manuscript; available in PMC: 2018 Jul 24.
Published in final edited form as: Nature. 2018 Jan 24;555(7695):269–273. doi: 10.1038/nature25758

Figure 2. Comparison of the ligand binding pocket across the D2-like family receptors.

Figure 2

a, b, c, Surface representations of the ligand binding pockets of DRD2 (a), DRD3 (b) (PDB code 3PBL) and DRD4 (c) (PDB code 5WIU) are shown in transparent gray. d, A schematic representation of risperidone binding interactions at a 4.0 Å cut-off is shown. Hydrogen bonds are shown in grey dashed lines. Mutations of the amino acid in the red boxes reduces risperidone binding affinity by more than tenfold. The thermo-stabilizing mutation (I1223.40A) colored in blue. The outline of deeper hydrophobic pocket is colored as orange.