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. Author manuscript; available in PMC: 2018 Jul 24.
Published in final edited form as: Nature. 2018 Jan 24;555(7695):269–273. doi: 10.1038/nature25758

Extended Data Table 1. Affinities of antipsychotic drugs for thermostabilized mutant and wild-type RDR2.

Data represent mean Ki (pKi ± SEM) for competition binding experiments using [3H]-N-methylspiperone (0.8–1.0 nM) as radioligand. All data are the mean  ± SEM of three independent assays (n = 3 independent experiments).

Receptor Kj, nM (pKi±SEM) Risperidone Aripiprazole N-Methylspiperone Nemonapride Bifeprunox
DRD2
wild-type		 1.91
(8.84±0.19)		 6.28
(8.21±0.05)		 0.04
(11.06±0.18)		 0.03
(11.06±0.10)		 1.04
(9.52±0.38)
DRD2
I1223.40A/L3756.37A/L3796.41A		 1.86
(9.10±0.38)		 1.25
(8.91±0.04)		 0.09
(11.01±0.11)		 0.05
(11.03±0.06)		 0.24
(9.62±0.02)
DRD2-T4L(Sf9)
I1223.40A/L3756.37A/L3796.41A		 3.13
(8.57±0.18)		 1.88
(8.73±0.02)		 0.06
(11.02±0.04)		 0.09
(11.03±0.33)		 0.57
(9.25±0.03)