Table 2.
Association of HLA-A/B/DRB1 allele groups with protection in CHMI.
| HLA | n | Odds Ratio | 95% CI | p value |
|---|---|---|---|---|
| HLA-A*01 | 53 | 2.36 | 1.15–4.81 | 0.019 |
| HLA-A*03 | 49 | 0.44 | 0.21–0.91 | 0.026 |
| HLA-B*08 | 44 | 2.51 | 1.16–5.44 | 0.020 |
| HLA-B*53 | 15 | 0.16 | 0.04–0.66 | 0.011 |
| HLA-DRB1*15/*16 | 79 | 1.90 | 1.03–3.50 | 0.041 |
| HLA-DRB1*07 | 56 | 0.36 | 0.18–0.73 | 0.005 |
HLA = broad serotype; n = number of subjects positive for allele group. Odds ratio, 95% confidence interval (CI), and p value refer to comparison of proportion of subjects protected between subjects positive and negative for an allele group using logistic regression and adjusting for trial, adjuvant, and schedule.