Table 5.
Association of HLA-A/B/DRB1 allele groups with protection in CHMI after adjustment for anti-CS antibody titre on the day of challenge.
| HLA | n | Odds ratio | 95% CI | p value |
|---|---|---|---|---|
| HLA-A*01 | 52 | 2.02 | 0.89–4.56 | 0.091 |
| HLA-A*03 | 49 | 0.26 | 0.11–0.61 | 0.002 |
| HLA-B*08 | 43 | 1.72 | 0.72–4.09 | 0.223 |
| HLA-B*53 | 14 | 0.37 | 0.09–1.59 | 0.181 |
| HLA-DRB1*15/*16 | 78 | 1.85 | 0.94–3.65 | 0.077 |
| HLA-DRB1*07 | 56 | 0.37 | 0.17–0.82 | 0.014 |
HLA = broad serotype; n = number of subjects positive for allele group. Odds ratio, 95% confidence interval (CI), and p value refer to comparison of proportion of subjects protected between subjects positive and negative for an allele group using logistic regression and adjusting for trial, adjuvant, schedule, and anti-CS titres on the day of challenge.