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. 2018 Mar 8;8:4177. doi: 10.1038/s41598-018-22469-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of the impact of CBZ treatment on HOS, MG-63, Saos-2 and U-2 OS cells migration. (A) quantification of the migration rate in OS cells treated with different doses of CBZ or DMSO as control; CBZ 5 μM significantly decrease the migration rate of all OS cells tested; (B) representative images of wound healing assay on control and CBZ 5 μM treated cells; control HOS cells close the wound in 20 hours, whereas control MG-63, Saos-2 and U-2 OS in 40 hours; CBZ 5 μM treated OS cells can repair only a little percentage of the wound compared to their respective control cells.