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. 2018 Mar 8;8:4177. doi: 10.1038/s41598-018-22469-5

Figure 5.

Figure 5

OBLs mediated effect of CBZ on HOS, MG-63, Saos-2 and U-2 OS cells. (A) Quantification of the proliferation rate of OS cells co-cultured with CBZ 5 μM or DMSO (as control) pre-treated OBLs; presence of CBZ 5 μM pre-treated OBLs leads to an inhibition of proliferation of RANK-positive HOS, MG-63 and Saos-2 cells, whereas no effect is detectable in U-2 OS cells. (B) representative images of proliferation curves between control or CBZ 5 μM pre-treated OBLs and RANK-positive Saos-2 or RANK-negative U-2 OS GFP + cells. Bar scale = 100 μm.