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. 2018 Mar 8;8:4186. doi: 10.1038/s41598-018-22268-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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siAQP4 treatment induces decreased levels of AQP4 and Cx43 expression in primary astrocyte cultures. (A) siAQP4 induced a reduction of AQP4 at 6 and 24 h in primary astrocyte cultures measured by Western blot. The red band at 30 kDa corresponds to AQP4 protein (left panel) and the red band at 43 kDa is the Cx43 protein (right panel). The level of expression of both proteins is normalized to actin (in green at 45 kDa). (B) AQP4 shows a progressive decrease up to 24 h. Cx43 levels were decreased at 24 h, suggesting an indirect effect of siAQP4 on Cx43 expression. (*p < 0.05 compare to CTL for AQP4; **p < 0.05 compare to CTL for Cx43; values are represented as mean ± SEM).