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. 2018 Mar 8;8:4186. doi: 10.1038/s41598-018-22268-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo treatment of siAQP4 induces decreased expression of Cx43 in the cortex. Expression of Cx43 was decreased in the cortex 3 days after siAQP4 treatment as shown by Western blot assay with actin (45 kDa) used as a loading control (A), and by immunohistochemistry (B). In siGLO control animals, Cx43 protein was colocalized with GFAP in the astrocytic endfeet but was almost absent from the cortex of the siAQP4-treated rats (B). AQP4 and Cx43 also colocalize around blood vessels in the cortex of siGLO animals (C) but were both decreased after siAQP4 treatment (D), as shown by immunoreactivity quantification (A.U. Arbitrary Unit; E–F). Scale bars: B: 20 µm, D: 50 µm. *p < 0.05; values are represented as mean ± SEM.