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. 2018 Mar 8;8:4186. doi: 10.1038/s41598-018-22268-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of siAQP4 on astrocyte dye-coupling. (A) Scrape loading experiments (white dotted line) on astrocyte cultures revealed the effect of siAQP4 on astrocyte connectivity, evidenced by a decreased spread of Lucifer yellow (green) in the siAQP4-transfected astrocytes. Rhodamine B-Dextran loading (red) was similar and did not diffuse at distance from the site of scrape loading in both conditions. (B) Quantification of the fluorescence of Lucifer yellow confirmed the functional consequence of siAQP4-induced decrease of Cx43 (A.U. Arbitrary Unit). Scale bars: A, B: 50 µm; *p < 0.05; values are represented as mean ± SEM.