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. 2018 Mar 8;8:4186. doi: 10.1038/s41598-018-22268-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Modulation of miR19a, miR23a, miR130a, miR224, miR381 and miR384-5p expression after siAQP4 and siCx43 treatment. Relative expression of miRNA in the cortex of siAQP4- (A) and siCx43- (B) treated rat pups. RNU6-2 was used as a normalization control. Schematic representation of our hypothesis (C) and results (D) which suggest a siAQP4-induced up-regulation of miR224 which mediates the down-regulation of his target Cx43. Interestingly, siCx43 treatment induced a down-regulation of miR19a and miR224, which in turn, were not able to decrease AQP4 expression; *p < 0.05; values are represented as mean ± SEM.