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. 2018 Mar 8;9:992. doi: 10.1038/s41467-018-03386-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Temperature variation during operation. a The top surface of POLYRETINA has been imaged with a thermal camera while pulsed illumination has been provided from the bottom, as in the epiretinal configuration. The camera has been focused on the top electrodes and a ROI has been selected to measure the changes in surface temperature (cyan circle). Electrodes show higher value of baseline temperature because the metallic surface reflects part of the IR light used for the measurement. b Mean (±s.d.) changes in surface temperature measured in N = 4 prostheses. Data have been plotted has difference with respect to the baseline temperature measured for 5 min before pulsed illumination. The green bar represents the period of 2 h when light pulses have been applied (10 ms pulses, 20 Hz repetition rate, 1.22 mW mm⁻²). The dotted red line represents the maximal allowed temperature increase. c Mean (±s.e.m.) changes in surface temperature measured on the electrodes (left, N = 4 prostheses) or on the polymer area (right, N = 4 prostheses). For each prosthesis, n = 3 electrodes/areas have been sampled and averaged. d Mean (±s.d.) changes in surface temperature in the average surface, the electrode area or the polymer area are not significantly different (1.24 ± 0.29, 1.23 ± 0.20, 1.31 ± 0.21, respectively; one-way ANOVA, F = 0.0569, p = 0.9451)